Improvement of genistein content in solid genistein/-cyclodextrin complexes β
نویسندگان
چکیده
منابع مشابه
Encapsulation of genistein in amylose complexes
Introduction Isoflavones are natural bioactives associated with a variety of beneficial health effects including reducing the risk of cardiovascular disease, lowering the rate of some cancers and improving bone health among other claims (Kano et al., 2006). One of the most abundant aglycone form of isoflavones found in soybean is genistein, 4',5,7-trihydroxyisoflavone (Crupi et al., 2007). Geni...
متن کاملChanges in the anti-inflammatory activity of soy isoflavonoid genistein versus genistein incorporated in two types of cyclodextrin derivatives
BACKGROUND The isoflavonoid genistein represents the major active compound from soybean, the vegetal product from Glycine max (Fabaceae). The aim of this study is to prove that genistein was incorporated in two semisynthetic cyclodextrins, beta-cyclodextrin derivatives: hydroxypropyl-beta-cyclodextrin and randomly-methylated-beta-cyclodextrin as well as to compare the anti-inflammatory activity...
متن کاملEnhancing genistein bioavailability by amylose complexes
Oral delivery systems for bioactive materials have long been of interest in food applications due to their contribution to the functional and sensory properties. Amylose complexes with hydrophobic molecules can be used as a delivery system to the intestine having the advantages of being readily available, cheap, nontoxic and biodegradable. In this study genistein, a major soy isoflavone possess...
متن کاملUtility of cyclodextrins in the formulation of genistein part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins.
Isoflavones are suitable guest molecules for inclusion complex formation with cyclodextrins (CDs). The molecular encapsulation with CDs results in a solid, molecularly dispersed form and in a significantly improved aqueous solubility of isoflavones. Genistein, a key isoflavone constituent of Ononidis spinosae radix was found to form a supramolecular, non-covalent inclusion complex with both bet...
متن کاملEffects of Radiation on the Protein and DNA Content in Genistein Treated Swiss Albino Mice
Genistein is a soya isoflavone, which is found naturally in legumes, such as soybeans and chickpeas. The intraperitoneal administration of the optimum dose (200 mg/kg) of genistein 24 h and 15 minbefore irradiation (8 Gy at a dose rate of 1.02 Gy/min) recovered the deficit in protein content (28.63±1.44%) and the DNA content (21.61±8.19%) if an average of 5 intervals of autopsies 1st...
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ژورنال
عنوان ژورنال: Química Nova
سال: 2010
ISSN: 0100-4042
DOI: 10.1590/s0100-40422010000300019